When you first start taking Align, you may notice changes as your body adjusts, and we suggest you continue to take Align to get the best results, as some consumers start to see changes after 14 days of consistent use. Our formulas undergo thorough testing to be safe and effective when used as directed, and everybody responds differently. However, if you have concerns, please discontinue and check with your doctor. We'd like to learn more about your experience and have our Safety Team review your report. When you can, please call us at 1-800-208-0112, M - F, 9 am to 6 pm EST.