A couple of questions: - Do you use other creams or lotions? - Do you take medications that might have cramping as a side effect? Any other info you care to provide might help us research how to get it working for you. The reason I ask about the "other creams or lotions" is that they can act as barriers to our product working (even moisturizers, things like that)…just something to be aware of. I have best results applying after a shower to dried, "clean" skin on my calves. Some more information that may help you out: To prevent cramps and spasms, apply liberally to the typically affected muscle group(s) prior to when they typically occur (for example, before going to sleep if you suffer nightly). The typical dosage is 2-4 pumps per muscle group, but some users may require another pump or two to get full coverage. (For me, I use 5 to 6 pumps, let it dry, then apply again) When you apply the product, please include the full muscle group, not just the typical point of cramping. For example, with your calf, apply from the back of the knee and all the way to your ankle to cover the full length of the calf muscle. We also recommend giving a little bit of "massage pressure" as you're applying the product. Keep rubbing it in until it is almost dry. Another new point to keep in mind...wait for the product to dry before getting in bed, or putting on clothes...we've discovered that the fabric might be soaking up the product off the skin, reducing its effectiveness. Please don’t hesitate to reach out for more information.