Instant Savings

Mucinex 12 Hour Cold and Flu Medicine for Adults, 50 Tablets

|607 ratings
Item # 990549445
Current price is Now $23.48
was $29.98
$0.47/ea
$6.50 off
Limit 4.Ends Sep 20
Prices may vary in club and online
How do you want your item?

Curbside Pickup

Free with your membership on eligible items
Columbus, Hilliard Sam's Club
Aisle E3
Return or replace anytime.
Sam's credit card
Get a $30 statement credit¹ when you open an account 9/1-9/30/26 + learn how to earn 10% back on fuel for a limited time‡ See details

Highlights

  •  The first and only over-the-counter cold and flu medicine that provides 12 hours of powerful multi-symptom relief
  • All Day Relief of Headache, Body Aches, Fever, Cough, & Chest Congestion
We also recommend

Flowflex Plus RSV Flu A/B Covid-19 Home Test

Flowflex Plus RSV Flu A/B  Covid-19 Home Test
Members-only price

Flowflex Plus RSV Flu A/B Covid-19 Home Test

4.8 out of 5 stars
4.8 out of 5 Stars. 1033 reviews
Sponsored
Mucinex 12 Hour Cold and Flu Medicine for Adults, 50 Tablets
Mucinex 12 Hour Cold and Flu Medicine for Adults, 50 Tablets
Hero image 0 of Mucinex 12 Hour Cold and Flu Medicine for Adults, 50 Tablets, 0 of 12

About this item

Product details

NEW MUCINEX 12 HOUR COLD & FEVER MULTI-SYMPTOM TABLETS

 Introducing the first and only over-the-counter 12 hour cold and flu medicine for adults that reduces fever and relieves cough, chest congestion, and body pain

ALL DAY OR NIGHT MULTI-SYMPTOM RELIEF

One dose lasts 3x longer than most cold & flu medicines (compared to 1 dose of 4-hour medicine without re-dosing)
FEVER REDUCTION & HEADACHE RELIEF: Contains Naproxen Sodium which reduces fever and relieves headache & minor pains

COUGH SUPPRESSANT

Contains Dextromethorphan HBr which helps control cough

info:
If the item details above aren't accurate or complete, we want to know about it. 

Specifications

HSA/FSA Eligible: Yes

Shelf Life: 24 Months

Allergy Alert: Naproxen sodium may cause a severe allergic reaction, especially in people allergic to aspirin. Symptoms may include:  

hives  

facial swelling  

asthma (wheezing)  

shock  

skin reddening  

rash  

blisters  

If an allergic reaction occurs, stop use and seek medical help right away.  

Stomach bleeding warning: This product contains an NSAID, which may cause severe stomach bleeding. The chance is higher if you:  

are age 60 or older  

have had stomach ulcers or bleeding problems  

take a blood thinning (anticoagulant) or steroid drug  

take other drugs containing prescription or nonprescription NSAIDs (aspirin, ibuprofen, naproxen, or others)  

have 3 or more alcoholic drinks every day while using this product  

take more or for a longer time than directed  

Heart attack and stroke warning: NSAIDs, except aspirin, increase the risk of heart attack, heart failure, and stroke. These can be fatal. The risk is higher if you use more than directed or for longer than directed.  

Do not use  

if you have ever had an allergic reaction to any other pain reliever/fever reducer  

for children under 12 years of age  

right before or after heart surgery  

if you are now taking a prescription monoamine oxidase inhibitor (MAOI) (certain drugs for depression, psychiatric or emotional conditions, or Parkinson's disease), or for 2 weeks after stopping the MAOI drug. If you do not know if your prescription drug contains an MAOI, ask a doctor or pharmacist before taking this product.  

Ask a doctor before use if  

the stomach bleeding warning applies to you  

you have a history of stomach problems, such as heartburn  

you have high blood pressure, heart disease, liver cirrhosis, kidney disease, asthma, or had a stroke  

you are taking a diuretic  

you have problems or serious side effects from taking pain relievers or fever reducers  

you have persistent or chronic cough such as occurs with smoking, asthma, chronic bronchitis, or emphysema  

you have a cough accompanied by too much phlegm (mucus)  

Ask a doctor or pharmacist before use if you are  

under a doctor’s care for any serious condition  

taking aspirin for heart attack or stroke, because naproxen may decrease this benefit of aspirin  

taking any other drug  

When using this product  

take with food or milk if stomach upset occurs  

Stop use and ask a doctor if you experience any of the following signs of stomach bleeding:  

feel faint  

vomit blood  

have bloody or black stools  

have stomach pain that does not get better  

you have symptoms of heart problems or stroke:  

chest pain  

trouble breathing  

weakness in one part or side of body  

slurred speech  

leg swelling  

pain gets worse or lasts more than 10 days  

fever gets worse or lasts more than 3 days  

you have difficulty swallowing  

it feels like the pill is stuck in your throat  

redness or swelling is present in the painful area  

any new symptoms appear  

cough lasts more than 7 days, comes back, or occurs with fever, rash, or persistent headache. These could be signs of a serious illness.  

If pregnant or breast-feeding, ask a health professional before use. It is especially important not to use naproxen sodium at 20 weeks or later in pregnancy unless definitely directed to do so by a doctor because it may cause problems in the unborn child or complications during delivery.  

Keep out of reach of children. In case of overdose, get medical help or contact a Poison Control Center right away.

Member ratings & reviews

4.8 out of 5 stars
stars
607 ratings607 reviews
Write a review
Filtered and sorted results would be available on the new 'Customer ratings & reviews' page.
Sort by |

Showing 1-3 of 607 reviews

Aug 13, 2026
Reviewer name: MelanieH
5 out of 5 stars
5 out of 5 stars review

Works great

[This review was collected as part of a promotion.] I have taken regular mucinex for a long time and when I saw this one I was hopeful it would work great, and it does! It helps with congestion and pain much faster, better, and longer than regular mucinex. This is definitely my new over the counter favorite for colds!

Review from Mucinex
Helpful?1RQMQLXT1NBQ6004981466
Aug 27, 2026
Reviewer name: AdeleP
5 out of 5 stars
5 out of 5 stars review

Very good product and fast acting

[This review was collected as part of a promotion.] I truly love mucinex products. This product helped me feel better very quickly and has no adverse symptoms for me. The pills are on the bigger side so some people may have problems swallowing them. The product has a very good price as well.

Review from Mucinex
Helpful?1RQMQLXT1NBQ6004981466
Sep 3, 2026
Reviewer name: KateS
5 out of 5 stars
5 out of 5 stars review

Provides relief

[This review was collected as part of a promotion.] After visiting the doctor for a regular check up, I caught a bug that wouldn't go away. I had a lot of congestion and coughing that lasted several days. I tried the Mucinex 12 hour cold and fever multi-symptom extended release tablets, and for the first time in days, I finally felt like myself again. These tablets are surprisingly effective, and they really did last all day for me. I would definitely recommend trying this Mucinex product next time you are dealing with a cold or fever. It worked great for me! 

Review from Mucinex
Helpful?1RQMQLXT1NBQ6004981466