Excedrin Extra Strength Pain Reliever Caplets, 300 ct.

|6,346 ratings
Item # 990351573
Current price is $18.98
$0.06/ea
Prices may vary in club and online
How do you want your item?

Shipping

Free for Plus on eligible orders over $50
Columbus, 43215
Return or replace anytime.
Sam's credit card
Get a $30 statement credit¹ when you open an account 9/1-9/30/26 + learn how to earn 10% back on fuel for a limited time‡ See details

Highlights

  • Relief for headaches, migraines, and other types of pain
  • Combination pain reliever with 2 pain fighters and 1 booster
  • For some, relief starts as soon as 15 minutes
  • Excedrin, a leader in headache relief for more than 50 years
We also recommend

Excedrin Migraine Pain Relief Caplets, 300 ct. $18.98 $0.06/ea

Excedrin Migraine Pain Relief Caplets, 300 ct.
current price $18.98
$0.06/ea

Excedrin Migraine Pain Relief Caplets, 300 ct.

4.765 out of 5 stars
4.765 out of 5 Stars. 6199 reviews
Sponsored
excedrin extra strength pain reliever caplets, 300 ct. Front-facing white plastic bottle with green screw cap and dark-green label reading Excedrin Extra Strength; label lists active ingredients acetaminophen, aspirin (NSAID) and caffeine, includes a white caplet graphic and '300 caplets' callout on a plain white background; label indicates relief for headaches, migraines and other types of pain.
Excedrin Extra Strength Pain Reliever Caplets, 300 ct.
Hero image 0 of Excedrin Extra Strength Pain Reliever Caplets, 300 ct., 0 of 7

About this item

Product details

For quick relief, reach for Excedrin Extra Strength Caplets. If you're dealing with headaches, migraines, or any other type of pain, many doctors recommend Excedrin Extra Strength before taking any prescription pain relievers.

Why Excedrin?

Excedrin Extra Strength Caplets provide the necessary relief you need whenever pain, migraines, and headaches strike. For many, relief starts just 15 minutes after you take your dose. For the past 50 years, Excedrin has been a trusted leader in headache and migraine relief. With Excedrin Extra Strength Caplets, you receive quick pain relief you can trust.

Relief for Minor Aches and Pains

Don't let aches and pains slow you down! Our formula provides trusted and quick relief for minor aches and pains that can be caused by tootaches, premenstrual and menstrual cramps, muscle aches, arthritis, headaces, and the cold. 

Ingredients

The three primary ingredients in Excedrin are 250 mg. of acetaminophen extra strength, 250 mg. of aspirin, and 65 mg. of caffeine. Both acetaminophen and aspirin fight pain for your relief, while the caffeine works to re-energize you. Also, research supports caffeine as a key contributor to headache and migraine relief. The combination of caffeine, acetaminophen, and aspirin increases the pain relieving effect by as much as 40%. 

info:
If the item details above aren't accurate or complete, we want to know about it. 

Specifications

  • 300 ct.
  • Acetaminophen 250 mg. - pain reliever
  • Aspirin 250 mg. - pain reliever
  • Caffeine 65 mg. - pain reliever aid
  • Ages 12 and older take 2 caplets every 6 hours
  • Drink a full glass of water with each dose
  • Ages 12 and under ask doctor before use
  • Use as directed

While we strive to obtain accurate product information, we cannot guarantee or ensure the accuracy, completeness or timeliness of any product information. Carefully read and follow all package directions. SamsClub.com assumes no liability for inaccuracies or misstatements about products.

Indications

Health Concern

Headache

Member ratings & reviews

4.7 out of 5 stars
stars
6,346 ratings5,854 reviews
Write a review
Filtered and sorted results would be available on the new 'Customer ratings & reviews' page.
Sort by |

Showing 1-3 of 5,854 reviews

Apr 20, 2026
Reviewer name: Tarheel
5 out of 5 stars
5 out of 5 stars review

Verified Purchase

Excedrin extra strength saves the day !

Excedrin extra strength saves the day ! Sometimes you get a headache that is pounding and won't go away. That is when nothing works as well as Excedrin for me. Give it an hour or so and the pain starts to lessen and go away. Must have in my medicine cabinet !

Review from walmart.com
Helpful?4GYNGM7F2P9K30067810433
Aug 14, 2026
Reviewer name: JC gardener
5 out of 5 stars
5 out of 5 stars review

Verified Purchase

More caplets more power

Great value for the quantity and it our preferred pain relief for severe migraines if taken at the onset.

Helpful?4GYNGM7F2P9K30067810433
Mar 12, 2026
Reviewer name: Michele
5 out of 5 stars
5 out of 5 stars review

Verified Purchase

This works

Disliked that the price has increased so much. Love the 300 ct availability. This is a terrific product for me; it is the only one that actually works for my headaches and body aches.

Review from walmart.com
Helpful?4GYNGM7F2P9K30067810433