Prilosec OTC Heartburn & Acid Reducer Tablets, 20 mg, 42 ct.

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Item # 990472137
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Highlights

  • 3 Pack - 14 Tablets per Pack
  • The first and original over the counter heartburn medicine
  • Treats frequent heartburn (occurring 2 or more days a week)
  • 14-Day Course of Treatment in each pack
  • Active ingredient of Omeprazole 20mg per Delayed-Release tablet

Nexium 24HR Acid Reducer Heartburn Relief Capsules with Esomeprazole Magnesium, 42 ct. $20.28 Was $25.28 $0.48/ea

Nexium 24HR Acid Reducer Heartburn Relief Capsules with Esomeprazole Magnesium, 42 ct.
current price Now $20.28, Was $25.28
$0.48/ea

Nexium 24HR Acid Reducer Heartburn Relief Capsules with Esomeprazole Magnesium, 42 ct.

4.7296 out of 5 Stars. 1653 reviews
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Prilosec OTC Heartburn & Acid Reducer Tablets, 20 mg, 42 ct.
Prilosec OTC Heartburn & Acid Reducer Tablets, 20 mg, 42 ct.
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About this item

Product details

Treats Frequent Heartburn

Prilosec OTC, Omeprazole Delayed Release 20mg, Acid Reducer, Treats Frequent Heartburn for 24 Hour Relief, All Day, All Night*, 20mg

#1 Doctor and Gastroenterologist Recommended

With one Prilosec OTC pill each morning, block your heartburn for a full 24 hours.* Heartburn happens when stomach acid refluxes into the esophagus. Prilosec OTC’s delayed-release formula helps it pass through the tough stomach acid, preventing excess acid production to block frequent heartburn.* Prilosec OTC is the #1 Doctor and Gastroenterologist recommended frequent heartburn medicine for over 15 years.† Contains the active ingredient omeprazole, an acid reducer that provides long-lasting, heartburn relief*

24 Hour Heartburn Relief

Prilosec OTC’s active ingredient, 20 mg of delayed released omeprazole, works to fight heartburn differently from treatments like acid controllers/H2s or antacids. Omeprazole blocks heartburn for a full 24 hours after taking one pill each morning.* Omeprazole is a proton pump inhibitor (PPI) and PPIs are a powerful class of frequent heartburn medicines. PPIs block heartburn by preventing excess acid production…something that antacids just can’t do. With 1 Prilosec OTC pill each morning, block heartburn for 24 hours,* unlike antacids which last only 1-3 hours.

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Specifications

  • Use Instructions:

Adults 18 years of age and older. This product is to be used once a day (every 24 hours), every day for 14 days. 

14-Day Course of Treatment:

Swallow 1 tablet with a glass of water before eating in the morning

Take every day for 14 days

Don not take more than 1 tablet a day

Do not use for more than 14 days unless directed by your doctor

Swallow whole. Do not chew or crush tablets

  • Purchase Includes: 42 Total Tablets
  • FSA/HSA Eligible: Yes
  • Allergen + Warnings:

Do not use if you are allergic to omeprazole

Keep out of reach of children. In case of overdose, get medical help or contact a Poison Control Center right away.

Before using ask a doctor or pharmacist if you are taking a prescription drug. Acid reducers may interact with certain prescription drugs. If you've had heartburn over 3 months this may be a sign of a more serious condition. 

Stop Using if your heartburn continues or worsens, you need to take this product more than 14 days, you get diarrhea, develop a rash or joint pain.

*Zero heartburn is possible with Prilosec OTC. Not for immediate relief. Take one pill per day as directed to treat frequent heartburn. May take 1 to 4 days for full effect. Compared to how antacids for heartburn. Use all heartburn medications as directed. Do not take for more than 14 days or more often than every 4 months unless directed by a doctor. Not for immediate relief.

† IQVIA ProVoice Survey, 2005 – 2022

  • Ingredients: Active Ingredient (in each tablet): Omeprazole Delayed-Release Tablet 20 mg (Equivalent to 20.6 mg Omeprazole Magnesium) (Acid Reducer). Inactive Ingredients: Glyceryl Monostearate, Hydroxypropyl Cellulose, Hypromellose, Iron Oxide, Magnesium Stearate, Methacrylic Acid Copolymer, Microcrystalline Cellulose, Paraffin, Polyethylene Glycol 6000, Polysorbate 80, Polyvinylpyrrolidone, Sodium Stearyl Fumarate, Starch, Sucrose, Talc, Titanium Dioxide, Triethyl Citrate"

Indications

Health Concern

Heartburn

Member ratings & reviews

4.8 out of 5 stars
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1,343 ratings236 reviews
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Showing 1-3 of 236 reviews

Jan 20, 2026
Mary
5 out of 5 stars review

Verified Purchase

Quick Relief

It works quickly allowing me fast relief and moving on with my day.

Helpful?155JS8E8WCCM3700027004
Jun 23, 2024
SN10306
5 out of 5 stars review

Verified Purchase

Pretty Great Results.

This worked better than expected! I’ve been taking Dexilant here and there when I’ve had severe heartburn but didn’t have any more. This was excellent, and I’ve been able to eat almost anything I like without much regard to the consequences of GERD for the most part. I highly recommend you try this. It worked within hours of the first dose although it said it could take a few days for relief in the instructions.

Helpful?155JS8E8WCCM3700027004
Apr 14, 2023
Blah Blah Blah
5 out of 5 stars review

Verified Purchase

Prilosec

Doctor told me to take the 14 takes doses and then take one Pepcid per day for the rest of my life and then I won't have heartburn anymore. So far I'm just finishing up the 14 day doses of one tablet a day. Each day I take the Prilosec I'm heart burn free.

Helpful?155JS8E8WCCM3700027004