Prilosec OTC Heartburn & Acid Reducer Tablets, 20 mg, 42 ct.

Item # 990472137
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Highlights

  • 3 Pack - 14 Tablets per Pack
  • The first and original over the counter heartburn medicine
  • Treats frequent heartburn (occurring 2 or more days a week)
  • 14-Day Course of Treatment in each pack
  • Active ingredient of Omeprazole 20mg per Delayed-Release tablet

Nexium 24HR Acid Reducer Heartburn Relief Capsules with Esomeprazole Magnesium, 42 ct. $20.28 Was $25.28 $0.48/ea

Nexium 24HR Acid Reducer Heartburn Relief Capsules with Esomeprazole Magnesium, 42 ct.
current price Now $20.28, Was $25.28
$0.48/ea
You save $5.00

Nexium 24HR Acid Reducer Heartburn Relief Capsules with Esomeprazole Magnesium, 42 ct.

4.7293 out of 5 Stars. 1651 reviews
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Prilosec OTC Heartburn & Acid Reducer Tablets, 20 mg, 42 ct.
Prilosec OTC Heartburn & Acid Reducer Tablets, 20 mg, 42 ct.
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About this item

Product details

Treats Frequent Heartburn

Prilosec OTC, Omeprazole Delayed Release 20mg, Acid Reducer, Treats Frequent Heartburn for 24 Hour Relief, All Day, All Night*, 20mg

#1 Doctor and Gastroenterologist Recommended

With one Prilosec OTC pill each morning, block your heartburn for a full 24 hours.* Heartburn happens when stomach acid refluxes into the esophagus. Prilosec OTC’s delayed-release formula helps it pass through the tough stomach acid, preventing excess acid production to block frequent heartburn.* Prilosec OTC is the #1 Doctor and Gastroenterologist recommended frequent heartburn medicine for over 15 years.† Contains the active ingredient omeprazole, an acid reducer that provides long-lasting, heartburn relief*

24 Hour Heartburn Relief

Prilosec OTC’s active ingredient, 20 mg of delayed released omeprazole, works to fight heartburn differently from treatments like acid controllers/H2s or antacids. Omeprazole blocks heartburn for a full 24 hours after taking one pill each morning.* Omeprazole is a proton pump inhibitor (PPI) and PPIs are a powerful class of frequent heartburn medicines. PPIs block heartburn by preventing excess acid production…something that antacids just can’t do. With 1 Prilosec OTC pill each morning, block heartburn for 24 hours,* unlike antacids which last only 1-3 hours.

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Specifications

  • Use Instructions:

Adults 18 years of age and older. This product is to be used once a day (every 24 hours), every day for 14 days. 

14-Day Course of Treatment:

Swallow 1 tablet with a glass of water before eating in the morning

Take every day for 14 days

Don not take more than 1 tablet a day

Do not use for more than 14 days unless directed by your doctor

Swallow whole. Do not chew or crush tablets

  • Purchase Includes: 42 Total Tablets
  • FSA/HSA Eligible: Yes
  • Allergen + Warnings:

Do not use if you are allergic to omeprazole

Keep out of reach of children. In case of overdose, get medical help or contact a Poison Control Center right away.

Before using ask a doctor or pharmacist if you are taking a prescription drug. Acid reducers may interact with certain prescription drugs. If you've had heartburn over 3 months this may be a sign of a more serious condition. 

Stop Using if your heartburn continues or worsens, you need to take this product more than 14 days, you get diarrhea, develop a rash or joint pain.

*Zero heartburn is possible with Prilosec OTC. Not for immediate relief. Take one pill per day as directed to treat frequent heartburn. May take 1 to 4 days for full effect. Compared to how antacids for heartburn. Use all heartburn medications as directed. Do not take for more than 14 days or more often than every 4 months unless directed by a doctor. Not for immediate relief.

† IQVIA ProVoice Survey, 2005 – 2022

  • Ingredients: Active Ingredient (in each tablet): Omeprazole Delayed-Release Tablet 20 mg (Equivalent to 20.6 mg Omeprazole Magnesium) (Acid Reducer). Inactive Ingredients: Glyceryl Monostearate, Hydroxypropyl Cellulose, Hypromellose, Iron Oxide, Magnesium Stearate, Methacrylic Acid Copolymer, Microcrystalline Cellulose, Paraffin, Polyethylene Glycol 6000, Polysorbate 80, Polyvinylpyrrolidone, Sodium Stearyl Fumarate, Starch, Sucrose, Talc, Titanium Dioxide, Triethyl Citrate"

Indications

Health Concern

Heartburn

Member ratings & reviews

4.8 out of 5 stars
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1,341 ratings235 reviews
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Showing 1-3 of 235 reviews

May 14, 2026
Kevin Jones
5 out of 5 stars review

Verified Purchase

Prilosec

Works really good for acid reflux

Helpful?155JS8E8WCCM3700027004
Jul 20, 2026
SMack
5 out of 5 stars review

Verified Purchase

Great

We use this or the generic form. Works great for a great price.

Helpful?155JS8E8WCCM3700027004
May 25, 2026
TD
5 out of 5 stars review

Verified Purchase

Prolosec OTC

Best tablets for indigestion. The only ones that help me.

Helpful?155JS8E8WCCM3700027004