Excedrin Extra Strength Pain Reliever Caplets, 300 ct.

|6,365 ratings
Item # 990351573
Current price is $18.98
$0.06/ea
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Highlights

  • Relief for headaches, migraines, and other types of pain
  • Combination pain reliever with 2 pain fighters and 1 booster
  • For some, relief starts as soon as 15 minutes
  • Excedrin, a leader in headache relief for more than 50 years
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excedrin extra strength pain reliever caplets, 300 ct. Front-facing white plastic bottle with green screw cap and dark-green label reading Excedrin Extra Strength; label lists active ingredients acetaminophen, aspirin (NSAID) and caffeine, includes a white caplet graphic and '300 caplets' callout on a plain white background; label indicates relief for headaches, migraines and other types of pain.
Excedrin Extra Strength Pain Reliever Caplets, 300 ct.
Hero image 0 of Excedrin Extra Strength Pain Reliever Caplets, 300 ct., 0 of 7

About this item

Product details

For quick relief, reach for Excedrin Extra Strength Caplets. If you're dealing with headaches, migraines, or any other type of pain, many doctors recommend Excedrin Extra Strength before taking any prescription pain relievers.

Why Excedrin?

Excedrin Extra Strength Caplets provide the necessary relief you need whenever pain, migraines, and headaches strike. For many, relief starts just 15 minutes after you take your dose. For the past 50 years, Excedrin has been a trusted leader in headache and migraine relief. With Excedrin Extra Strength Caplets, you receive quick pain relief you can trust.

Relief for Minor Aches and Pains

Don't let aches and pains slow you down! Our formula provides trusted and quick relief for minor aches and pains that can be caused by tootaches, premenstrual and menstrual cramps, muscle aches, arthritis, headaces, and the cold. 

Ingredients

The three primary ingredients in Excedrin are 250 mg. of acetaminophen extra strength, 250 mg. of aspirin, and 65 mg. of caffeine. Both acetaminophen and aspirin fight pain for your relief, while the caffeine works to re-energize you. Also, research supports caffeine as a key contributor to headache and migraine relief. The combination of caffeine, acetaminophen, and aspirin increases the pain relieving effect by as much as 40%. 

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Specifications

  • 300 ct.
  • Acetaminophen 250 mg. - pain reliever
  • Aspirin 250 mg. - pain reliever
  • Caffeine 65 mg. - pain reliever aid
  • Ages 12 and older take 2 caplets every 6 hours
  • Drink a full glass of water with each dose
  • Ages 12 and under ask doctor before use
  • Use as directed

While we strive to obtain accurate product information, we cannot guarantee or ensure the accuracy, completeness or timeliness of any product information. Carefully read and follow all package directions. SamsClub.com assumes no liability for inaccuracies or misstatements about products.

Indications

Health Concern

Headache

Member ratings & reviews

4.7 out of 5 stars
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6,365 ratings5,871 reviews
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Showing 1-3 of 5,871 reviews

Sep 21, 2026
Reviewer name: AshleyA
5 out of 5 stars
5 out of 5 stars review

Products works

[This review was collected as part of a promotion.] Excedrin Extra Strength is my go to for those stubborn body aches & pains that just won't go away. Great product and works within 10-15 minutes. Texture is great providing a nice coating to easily swallow the pills. I would recommend this product for aches, pains and body aches.

Review from Excederin
Helpful?4GYNGM7F2P9K30067810433
Sep 11, 2026
Reviewer name: LisbetC
5 out of 5 stars
5 out of 5 stars review

Relieves headache quickly, cleanly and with a very long-lasting effect.

[This review was collected as part of a promotion.] Since I tried this product I was surprised, the consistency of its results is excellent. The dosage of two tablets is perfect to stop the headache quickly. It leaves no feeling of stomach heaviness or traces of bitter taste. In addition, the duration of its effect is prolonged, which allows me to continue with my day without relapses.

Review from Excederin
Helpful?4GYNGM7F2P9K30067810433
Sep 23, 2026
Reviewer name: SilviaF
5 out of 5 stars
5 out of 5 stars review

Go-to for cycle and muscle soreness

[This review was collected as part of a promotion.] This review is 100%. My honest opinion, That I usually Reach For Tylenol, so I Was curious to try Excedrin Extra Strength. I Have used it for two things. The heavy headache I Get With My cycle and The Muscle sourness After CrossFit That both Times. I felt relief in less Than an hour That. The Moment That sold Me Was a Day I Had a pounding headache while taking care of my Daughter That There is no laying Down Until It passes When You Are a Mom, and This Let Me Keep Going With My Day. My Only Small Complaint is That The 2 is Two couplet instead of One, which is in a big deal, but it's worth knowing that overall it's Earned permanent spot in my bags

Review from Excederin
Helpful?4GYNGM7F2P9K30067810433