ive taken this for 2 yrs %26 notice a drop in energy %26 productivity if i stop. it takes a few days to make a difference in your body. i checked with my doctor who says it helps inflamation. i have not purchased this bottle. i started with 300mg %26 Ive switched to 500mg. my doctors nurse gets this in shot form. it is expensive, but it has definitely improved my life. im glad Sams offers it. if you go to Tru Nigen web site theres a quiz to tell you which dose it recommends based on your lifestyle. Since its become popular you no longer can find a capsule thats 300mg %26 you get 90. Its well researched but the company that makes it has gotten greedy. If you feel it takes longer to get things done, try this. like most meds it takes time to build in your body. i take other medication so consulted my doctor.